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In DFU, notch pathway dysfunction can lead to inhibition of cell differentiation, proliferation disorders, and reduced angiogenesis, all of which interfere with diabetic wound healing

[PubMed | ClinicalTrials.gov | DOI] Sources &

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When B12 levels are too low, the nerves can become damaged, leading to sensations like numbness, tingling, or a pins and needles feeling in the hands, feet, or legs

Abstract Cancer is a major disease with ever-increasing morbidity and mortality

Pellatt, AJ, Maddalena, G, Bent, AH, Parseghian, C, Huey, RW, Raghav, KS, Morris, VK, Overman, MJ, Morelli, MP, Willis, JA, Le, PH, Shen, JY, Alfaro, KD, Aziz, KE, Kell, R, Sun, R, Kopetz, S , Dasari, NV