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In some embodiments, an otic composition or formulation disclosed herein comprises less than about 5 ppm of each of alcohols, propylene glycol, and cyclohexane

Improved sleep depth and onset within 5-10 days, measurable telomere lengthening after 2-3 months, increased energy, better stress resilience

Chemical Biology & Drug Design, 81(1), 136-147

This is not only acceptable but often optimal

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In more severe casessuch as full-thickness tendon tears, persistent pain after 6 months of therapy, or functional loss arthroscopic rotator cuff repair may be warranted