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Although extensive studies on the effects of exogenous GSH have been performed, results on the stress responses were still differential across different studies, particularly the variable response of the antioxidant enzymatic activities, where some studies reported a decrease in enzymatic activities albeit an increase in GSH/GSSG ratio (Goodarzi et al., 2020)

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Ionizing radiation from radiation therapy also induced HIF-1 accumulation, which resulted in nuclear translocation of SLC7A11 and inhibited ferroptosis in HCC (138)

doi: 10.1016/j.clnu.2018.05.018