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[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment

Typically administered weekly, they can be given intramuscularly or subcutaneously

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Peptides, especially larger ones, can be sensitive to mechanical stress