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Several studies have indicated that the capacity of flavanols and flavones to inhibit the active site is largely dependent on hydrogen bonds between the polyphenol ligand hydroxyl groups and the catalytic residues of the binding site [252]

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For androgenetic alopecia specifically, the most evidence-supported complete approach is: finasteride (prescription, primarily men) or minoxidil (OTC) as the pharmaceutical foundation, copper peptides as the daily cellular support layer, and scalp microneedling to amplify topical penetration

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