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Investigation of the precise signaling pathways involved in this process can offer valuable insights into the potential of targeting EVs-mediated gene transfer as a therapeutic strategy to modulate iron homeostasis and prevent tumorigenesis

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Hollow-needle microinfusion is delivery-focused (shallow depths, sealed serum, gentle stamping), while solid-needle microneedling at clinical depths is injury-focused (deeper needling, collagen induction through controlled wounding)