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The bottom line Before the discovery and medicinal use of vitamin B 12 in the 1930s and 1940s, deficiency could be fatal

However, researchers note these are in vitro measurements that do not directly translate to in vivo outcomes

While not acutely dangerous, its not advisable without medical supervision

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doi:10.1038/nri1860 79

Currently, synthetic and natural biomaterials are readily available today, enabling the creation of new wound dressings that substantially enhance wound healing