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Yes-after enzymatic cleavage of the cypionate ester, the released 17-estradiol is molecularly identical to endogenous human estrogen

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This revision came after reports of local IGF-1 production in non-hepatic tissues, including bone [142], demonstrating that IGF-1 acts as both an endocrine and autocrine/paracrine growth regulator

A significant downregulation of ER-, PR-A, PR-B, and steroid receptor coactivators in human myoma cells may be one of the mechanismsan effect similar to that observed during the course of hormone therapy with GnRH analogues and ulipristal acetate (UPA) [50,72,73]