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Who should not use tirzepatide: Do not use tirzepatide if you or any family member has ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

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Glutamine is transported to cells through the transporter SLC1A5 (member of solute carrier family 1 neutral amino acid transporter 5), and glutamate is generated under the catalysis of glutaminase (GLS or GLS2) as one of the raw materials for glutathione synthesis [92]