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Allergy 72, 385396

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The primary endpoint of the study is the relative change in body weight from baseline to week 68

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Research has confirmed no significant effects on serum IGF-1 levels, no negative effect on carbohydrate metabolism, and no immunogenicity with no anti-AOD-9604 antibodies detected in any participants

Moreover, certain ferroptotic signaling products actively reinforce this polarization: oxidized phospholipids serve as ligands for PPAR, a nuclear receptor that stabilizes M2 polarization while suppressing M1-like inflammatory gene expression (107, 108)