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Surprisingly, gliotoxin can also induce apoptosis in paclitaxel-resistant ovarian cancer cells via the upregulation of active p63 (TAp63), and it was demonstrated that the pretreatment of ovarian cancer cells with gliotoxin can inhibit the expression of drug-resistant proteins MDR1 and MRP1-3, thus inducing caspase-dependent apoptosis through autophagy after subsequent treatment with paclitaxel [89]

Su mecanismo de accin se relaciona con la promocin de la angiognesis, la modulacin de la expresin del factor de crecimiento endotelial vascular (VEGF) y la interaccin con el eje intestino-cerebro en modelos experimentales

Levy, MD, JD Cardiologist, Thomas Levy, M.D

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[DOI] [PubMed] [Google Scholar] 178.Monder C