(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field
Too much NNMT can lower NAD+ levels (low NAD+ levels may make it harder to burn fat efficiently or maintain metabolic health as you age)
But let's be honestimproper storage of this essential diluent can have catastrophic consequences for your research
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When to call a professional Contact your doctor for a physical examination if you experience unexplained fatigue, palpitations, shortness of breath, sore tongue, or any other symptoms of vitamin B 12 deficiency