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2 mg of native protein lysates were prepared in modified cell extraction buffer and incubated for 1.5 h at 4 C with slow rotation with anti-ACE2 (Abcam, ab15348, accession number: Q9BYF1) coated beads (5 g of antibody per mg bead) (optimisation of antibody in Supplementary Fig

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To predict 3-dimensional structures and the evaluation of molecular dynamic behaviors, MODELLER and GROMACS software are accessible, respectively (180)