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In response to an increase in the cytosolic Ca 2+ concentration, the Gardos channel opens, resulting in the efflux of K + with subsequent hyperpolarization driving Cl - exit (through Cl - channels)

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Folinic acid produced significant improvements in global ADOS score, social interaction, and communication, whereas placebo showed no meaningful change (Renard et al., 2020)

OTUD5 counteracts UBR5-mediated K48 ubiquitylation, overcome by TRIP12 To investigate whether OTUD5 counteracted ubiquitin chain assembly, we conducted an in vitro ubiquitylation/deubiquitylation assay using wild-type or catalytically inactive (C224R) OTUD5 (OTUD5C224R)

High-end Talent Introduction Project of the Science and Technology Department of Sichuan Province 2025HJRC0033