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A key extrinsic pathway component is the death receptor Fas (CD95), which, upon binding to Fas ligand (FasL/CD95L), recruits the adaptor protein FADD (Fas-associated death domain protein) and procaspase-8 to form the death-inducing signaling complex (DISC)

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Funding Supported by the University of Zagreb, Zagreb, Croatia (Grant BM 099)

Animal care was in compliance with standard operative procedures of Pharmacology Animal facility, the European convention for the protection of vertebrate animals used for experimental and other scientific purposes (ETS 123)