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FIGURE 1 3 Meta-analysis of random trials 3.1 Materials and methods 3.1.1 Search strategy This systematic review was conducted in accordance with PRISMA guidelines and prospectively registered in PROSPERO ( CRD42024602837 ) on 17 October 2024

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Heatmaps of the number and intensity of interactions between different cell type signaling pathways were generated using the netVisual_heatmap function, while bubble plots of significantly increased and decreased ligand-receptor pairs in GCGR-KO islets compared with WT islets was created using the netVisual bubble function

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