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Cagrilintide vs tirzepatide Tirzepatide is a dual GIP/GLP-1 agonist that produces the highest monotherapy weight loss results currently available, approximately 22.5% at the maximum dose

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Consistent with this observation, PERMANOVA analysis demonstrated no statistically significant difference between pre- and post-intervention metabolomes (F = 0.2135, R = 0.0117, p = 0.857), suggesting that the GF-MKD did not induce large-scale global metabolic remodeling