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Inflammatory cytokines contribute to brain endothelial cell activation and downregulation of tight junction proteins, such as zonula occludens-1 and claudin-5, resulting in bloodbrain barrier dysfunction [55]

If you prefer not to take it before working out, you can spread out your dose and take it with meals

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References Kurzhagen JT, Dellepiane S, Cantaluppi V, Rabb H