The metformins value as an OXPHOS inhibitor for cancer treatment remains a subject of contention, and prudence is advisable in its utilization for this purpose ( Since metformin intervention is safe and well-tolerated among patients, determining the most effective dose in terms of beneficial effects and disease prevention is a significant challenge ( 2 should not receive metformin due to the risk of metformin-associated lactic acidosis (MALA) ( 7 Limitation of metformin use Metformin, as a popular drug used in the treatment of T2DM, has its application and benefits in improving glycemic control and metabolism in many patients
Toxicology 149:4350 Thomas C, Mackey MM, Diaz AA, Cox DP (2009) Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation
Authors contributions Conceived and designed the experiments, supervision: HW ZL QY
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