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During sepsis, cytokine storms can lead to the overexpression of nitric oxide (NO) synthase on endothelial cells and the synthesis of NO, resulting in vasodilation and adrenergic hyporeactivity, which affects microcirculatory hemodynamics (135)

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The prolonged exposure of renal cells to oxidative damage impairs the ability of the tubules to transport, absorb, and excrete electrolytes and water, and leads to fibrosis and loss of kidney function

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Rapid, high yield assembly of difficult sequences