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Clinically, the U-shaped curve illustrates the risks associated with excessive antioxidant supplementation in the absence of proper professional oversight and individualized patient assessment [23]
In a randomized controlled trial in type 2 diabetics, 200 mg of CoQ10 daily for 12 weeks significantly decreased both systolic and diastolic blood pressure, by 6.1 mm Hg and 2.9 mm Hg, respectively
Urinary excretion is the primary elimination pathway
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Dringen, R., et al., Glutathione-Dependent Detoxification Processes in Astrocytes