However, increasing evidence points towards other sites of action that might also have an important role, including the gastrointestinal tract, the gut microbial communities and the tissue-resident immune cells
Pro-inflammatory cytokines, IL-1, TNF, and IL-6, contribute to tissue repair by enhancing phagocytic activity, excessive release leading to the upregulation of inducible nitric oxide synthase (iNOS), damaging neurons, and disrupting the bloodbrain barrierthe anti-inflammatory response results in neuroprotection by tissue repair, regeneration, and promoting angiogenesis (Figure 15)
Melanie Avalon Okay, so that should be per target body weight
For experiments in 384-well plates, wells were aspirated, rinsed with PBS and incubated with a fixative and staining solution containing 3.7% formaldehyde (Fisher Scientific, F75P-1GAL) and 5 g ml 1 Hoechst 33342, trihydrochloride, trihydrate (Invitrogen, H1399)
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