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The control + DSS mice contained much lower abundance of known mouse commensal taxa and higher abundance of the Clostridium sensu stricto clade (54), which contains known pathogens such as Clostridium perfringens (55), and well-known butyrate-producing symbionts, such as Clostridium butyricum (46)

These observations are consistent with emerging evidence connecting systemic metabolism, microbiome-derived metabolites, and neurological function 65,66 , and suggest that metabolic flexibility may contribute to recovery potential

Some natural ingredients were reported to target tyrosinase expression through MITF pathway, like resveratrol or -viniferin, a resveratrol oligomer that improved facial melasma and freckles [102]

Excessive free radicals are associated with many diseases: atherosclerosis, cataracts, cancer, Alzheimers, osteoarthritis, immune dysfunction, and more

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