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It could be cancer destroying healthy cells and releasing B12 back to the blood, a bad liver that can no longer store B12, or an increased production of the transport protein haptocorrin, to which blood B12 binds

75 That trial apparently completed in 2016 but never published results , and the investigators withdrew their planned results submission

Results vary based on individual metabolism, dosage, frequency, and lifestyle habits

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It decreases COX-2 gene expression, reduces myeloperoxidase activity, and lowers pro-inflammatory cytokines including IL-6 and TNF-alpha

It may also influence fibroblast activity and extracellular matrix remodeling, contributing to structural tissue repair