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It needs to be demonstrated whether NAFLD has an impact on the abundance of the genus Ruminococcus through GWAS data covering a larger population or additional experimental studies

Severe deficiency can contribute to fatty liver changes, which is one reason choline gets framed as liver support. Details are summarized in the NIH ODS Choline fact sheet for health professionals

Ruiz De Almodovar C, Lambrechts D, Mazzone M, Carmeliet P (2009) Role and therapeutic potential of VEGF in the nervous system

Enhancement of tonic and phasic GABAergic currents following nitric oxide synthase inhibition in hippocampal CA1 pyramidal neurons

Allaire M, et al

In endurance events, where glycogen depletion is a limiting factor, maximizing fat utilization can provide a more sustainable energy source, potentially delaying fatigue