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A., Ghafoori H., Farahmand Z., MohammadKhani E., Vakhshiteh F., et al
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A landmark 2011 cell study showed satellite-cell proliferation at doses as low as 3 ng/ml
By introducing additional A1AT through gene delivery using a recombinant adeno-associated virus, researchers were able to observe a significant reduction in insulitis and prevent the development of hyperglycemia in non-obese diabetic mice ( A notable finding in this context is the potential of A1AT to extend the survival of transplanted islet cells and regulate the immune response in a mouse model of islet cell transplantation (113, 114)
In order to further solidify their findings, the researchers analyzed the expression of the cell proliferation marker and the proliferating cell nuclear antigen (PCNA) in tendon fibroblasts at the RNA expression level through the use of RT-PCR