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While no fetal structural abnormalities occurred in either species, maternal toxicity, characterized by reduced body weight gain, and reduced fetal weights occurred in rabbits at the highest dose (exposures 50 times the human exposure at the MRHD of 1 mg twice daily based on AUC)

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Strategies can include: Nicotine Replacement Therapy (NRT) : This approach uses patches or gum to help gradually ease withdrawal symptoms