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Up-regulation of membrane transporters and metabolic enzymes would enhance the amino acid uptake and synthesis, respectively [17].The cells may also recycle proteins and organelles to re-generate non-essential amino acids by autophagy [18]

Both exogenous and endogenous antioxidants can manipulate the ROS levels, by regulating gene expression and signaling pathways, and eventually maintain the oxidative balance and the integrity of cellular components (24, 121)

Ferroptotic macrophages can trigger a systemic inflammatory response by releasing DAMPs and pro-inflammatory cytokines that can activate the inflammasome

Neutralization of SARS-CoV-2 pseudovirus using ACE2-engineered extracellular vesicles

Unify skin tone and improve its overall appearance

Improves skin texture and tightness Verdict: Best for quick and long-lasting results, especially for moderate to severe pigmentation