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These include: Lifestyle interventions (dietary advice, physical activity programmes) Licensed pharmacotherapy such as orlistat, or GLP-1 receptor agonists including semaglutide 2.4 mg (Wegovy, NICE TA875) or tirzepatide (Zepbound) where clinically indicated and available Referral to tier 3 or tier 4 weight management services , including bariatric surgery assessment where appropriate Information on NHS weight management services and eligibility for licensed treatments is available via the NHS website and NICE guidance

Schrder K

Measurements showed increased skin density and thickness, suggesting enhanced collagen content

Weight loss plateau lasting more than 4 weeks A plateau of 2 to 3 weeks is normal and does not require dose changes

Dietary interventions The study implemented an IF regimen for the intervention group, allowing only non-caloric beverages during a 16-hour fasting period and unrestricted eating for 8 h