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References: Baker JF (2026): Diagnosis and differential diagnosis of rheumatoid arthritis

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The M1 phenotype, stimulated by lipopolysaccharide (LPS) and interferon- (IFN-), was used as a positive control, whereas the M2 phenotype, induced by interleukin-4 (IL-4), functioned as a negative control

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But stress and a poor diet can cause toxins to build up on the receptors, inhibiting their lipid-releasing function