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The medication is not recommended during pregnancy, in patients with severe gastrointestinal disease including severe gastroparesis, or in those with a history of pancreatitis

Temporary blood glucose fluctuations have been observed, emphasizing the need for close monitoring in these cases

Research references 10 mcg/kg in animals, and human practice typically uses 200 to 800 mcg per day

doi: 10.11607/jomi.te09

Ferroptosis contributes to articular cartilage destruction in RA, and Yang et al

Long-term safety, repeated-dose effects, interactions with other sleep aids or hormones (such as growth hormone, cortisol, stress hormones) remain underexplored