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The body further oxidizes acetate to carbon dioxide and water in peripheral tissues

Vitamin B12 plays a significant role in several body functions, including red blood cell production

Notably, increased NAD+ levels also activate NAD+dependent signaling pathways such as sirtuins (SIRT1/SIRT3), further enhancing mitochondrial biogenesis and energy metabolism

doi: 10.3389/fimmu.2020.01007 Received 21 February 2020 Accepted 28 April 2020 Published 28 May 2020 Volume 11 - 2020 Edited by Laxmi Yeruva, University of Arkansas for Medical Sciences, United States Reviewed by Barbara Wrblewska, Institute of Animal Reproduction and Food Research (PAN), Poland