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mGlu2 receptors are found in many stations of the pain neuraxis and negatively modulate pain transmission in the first pain synapse between primary afferent fibers and second-order neurons in the dorsal horns of the spinal cord [164]

doi: 10.1080/20002297.2020.1742527, 126 SchtzleM.LeH.BrginW.AnerudA.BoysenH.LangN

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Variants of this gene can affect the activity of the GPx-1 enzyme