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In contrast, male lifespan tended to be reduced by early-life IGF-1 deficiency, which is in agreement with a prior study in LID mice 41

The GSH-mediated regulation of ferroptosis has shown some promising results in the treatment of ischemic injury to the liver, kidney, brain, and heart as well as some neurodegenerative diseases [18]

Low total GSH and high homocysteine levels are considered as novel risk markers for acute stroke severity, and low total and reduced GSH levels may be potential risk markers for stroke severity and insufficient functional independence in large-artery atherosclerosis (157, 158)

Biswas SK, Rahman I

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Gastrointestinal and hepatic complications of sickle cell disease