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These data are preliminary and derive from bioinformatics analyses, but they form the basis for further in vivo studies
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TGF-1-induced tubular lipid peroxidation (linked to renal failure) is reversed by GPX4 (206), while GPX4 deficiency exacerbates TGF-1 production and fibrosiseffects reversed by GPX4 upregulation (207)
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However, gut dysbiosis in PCOS is associated with a decline in SCFAs-producing and BA-metabolizing bacteria, leading to a shift toward pro-inflammatory microbial communities and a reduction in anti-inflammatory taxa (54, 55)