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pylori stimulates a systemic immunosuppressive T helper 2 (Th2)/macrophage M2 response and activates the NLR family pyrin domain containing 3 (NLRP3) inflammasome, followed by IL-1 and IL-18 cytokine secretion, which, together with a Treg-skewed response, protects from the development of IBD (Engler et al., 2015

To confirm the metabolic changes, we next performed targeted Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) analysis of plasma and ovarian tissues

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