This redox balance is not merely a bystander in cellular homeostasis but a fundamental determinant of protein folding quality control
However, GSH-deficient FoB accumulate defective mitochondria and do not activate upon viral challenge
However, the mechanisms by which tumor cells coordinate TME stimuli and their unique metabolic traits to evade ferroptosis and develop resistance to immunotherapy remain unclear
Cell death serves not only as a physiological mechanism controlling normal development and tissue balance, but also as a pathological process triggering organ dysfunction and causing local or systemic inflammation
Existing studies have shown that the main features of depression are abnormal neurotransmitter levels in patients, abnormal function of the hypothalamic-pituitary-adrenal (HPA) axis, hormonal imbalance in the organism with inflammation and oxidative stress, neurotrophic factors, tryptophan metabolism, and the occurrence of gut microbiota-related diseases, as shown in Figure 1
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