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2.2 Patient samples Peripheral blood was obtained from 30 treatment-nave patients with CLL who provided written informed consent as part of a protocol approved by the Institutional Review Board of MD Anderson Cancer Center and in accordance with the Declaration of Helsinki
Glutathione is synthesized from glycine, cysteine, and glutamate in a two-step process that occurs in the cytosol of all cells
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Together, these findings suggest that CBS refuels cysteine pools for GSH synthesis through de novo cysteine biosynthesis under cystine restricted conditions