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Modern pharmacologic therapies (including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs) remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity

In some embodiments, the amount of thermoreversible polymer (e.g., pluronic F127) in any formulation described herein is about 13% of the total weight of the formulation

The treatment enhanced the PI3K (phosphoinositide 3 kinase)/Akt pathway

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Cell communication and signaling: CCS

Acta, Proteins Proteomics 130 PicaA.Russo KraussI.CastellanoI.RossiM.La CaraF.GrazianoG.et al (2012)