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Further, a near perfect correlation between mRFP--actin labeled spines and the general presynaptic marker Synapsin and VLGUT1 staining, which identifies excitatory glutamatergic synapses suggests that most AngIV-dependent effects on hippocampal spines were restricted to excitatory synapses

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(4) combining drug delivery with local CSF removal ("pharmacodialysis") to clear the affected/treated tissue

Age remains the single strongest predictor of egg quality, not because of a fixed biological clock, but because of the cumulative effects of oxidative stress and mitochondrial decline on eggs that have been dormant in your ovaries since before birth

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