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For a substance or method to be added to the List, it must be determined that it meets at least two of the following three criteria: It has the potential to enhance or enhances sport performance It represents an actual or potential health risk to the athletes It violates the spirit of sport The List is released three months ahead of it taking effect so that athletes, their entourage and other stakeholders can acquaint themselves with any modifications

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Morphine has a bioavailability of about 30% because 70% is metabolized via 1st pass effect (metabolism by the liver) if taken orally

The published research base, predominantly preclinical with growing clinical extension, identifies several mechanisms of action