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According to the American Society for Dermatologic Surgery, the FDA proposed an OTC ban way back in 2006, recommending more studies by the National Toxicology Program (NTP) due to as-yet-unproven concerns that it may cause cancer, as well as concerns over ochronosisskin darkening (in other words, the opposite of what most hydroquinone users are going for)

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Product Information The compound is the grade of analytical standard, which is the reference standard supplied assay

This decline doesnt happen all at once, but slowly, often unnoticed at first