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In mice, 3-AR receptors mediate cold-induced thermogenesis (223) and pharmacological activation of 3-ARs acutely stimulate lipolysis leading to two-fold increase in energy expenditure, a dramatic ten-fold increase in insulin levels, and 4050% reduction in food intake (98)

These quality parameters are especially relevant in studies where inflammatory signaling or immune interference must be carefully controlled

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In the USA and EU, AOD-9604 never achieved regulatory approval

Since its primarily found in animal products, those following a vegan or vegetarian lifestyle must find alternative sources

AOD-9604 triggers fat release from obese fat cells more predominantly than lean ones