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According to an article titled Mixing Alcohol with Medicines written by the National Institute on Drug Abuse (NIDA) 2020, mixing stimulants with alcohol significantly heightens the risk of cardiovascular problems and behavioral issues

Conclusions: Our results suggest that passive cigarette smoking may reduce epinephrine vasodilation and increase hypertensive response when compared to felypressin

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Given that ROS generation is highly time-sensitive, it is possible that earlier timepoints in the DC model would yield more sensitive readouts of oxidative stress dynamics