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Berndt C, Hanschmann EM, Jordt LM, Gellert M, Thewes L, Salas CO, et al
(IV) The metal nanomedicines show great potential for cancer therapy not only because of the capability of GSH exhaustion, but also for their wide range of other biological effects, such as interference with osmotic pressure, regulation of the immune system, and activation of biocatalysis (Hu et al., 2022)
May delay oral drug absorption
Journal of Pharmacology and Experimental Therapeutics 303 , 10611066 (2002)
Month 9: Interim technical progress briefing (live system demo with annotated slides) to the DARPA PM (in-person or virtual as needed) detailing progress made (include quantitative assessment of capability developed to date), tasks accomplished, major risks/mitigations, planned activities, and technical plan for the remainder of Phase II, the demonstration/verification plan for the end of Phase II, trip summaries, and any potential issues or problem areas that require the attention of the DARPA PM
The specific binding site is located in the allosteric drug and metabolic site (ADaM), which is a hydrophobic pocket in which reversible and competitive binding such as AMP occurs (Dhanya et al., 2017)
