They found that glutathione was significantly lower in several key brain areas in the participants with first-episode psychosis, lending support to the concept that oxidative stress in the central nervous system plays an important role in its pathophysiology. Authors of the third paper reported that participants with first-episode psychosis performed significantly worse on cognitive tests compared with controls
patent 6,288,079 1 2 European Journal of Pharmacology
Sample or standard was added to GCL reaction buffer (400 mM Tris, 40 mM ATP, 20 mM L-glutamic acid, 2.0 mM EDTA, 20 mM sodium borate, 2 mM serine, and 40 mM MgCl 2 )
J Therm Anal Calorim 102:203210
Another critical, and often underappreciated, consideration is the pharmacological selectivity of GlyT1 inhibitors within the broader SLC6 family, which comprises closely related transporters such as GlyT2 (SLC6A5) and PROT (SLC6A7), as well as several monoamine transporters (e.g., DAT, SERT, and NET) (de Carvalho et al
PMID: 39 LarnderAHMangesARMurphyRA
